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Updated: Feb 7, 2026
05:23
Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
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Non-neuronal targets for migraine therapy
Otilia Gliga1, Albert Feliu-Soler2, Marta Vila-Pueyo1
1Headache and Neurological Pain Research Group, Vall d'Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, 119-129 Passeig de la Vall d'Hebron, 08035 Barcelona, Spain.
Summary
Non-neuronal cells like astrocytes and microglia play a key role in migraine pathophysiology. Targeting these cells, along with others such as mast cells, offers promising avenues for novel migraine treatments.
Area of Science:
- Neurology
- Cell Biology
Background:
- Migraine is a severe neurological disorder impacting millions globally.
- Current understanding of migraine pathophysiology primarily focuses on neuronal involvement.
- Emerging evidence highlights the significant role of non-neuronal cells in migraine.
Purpose of the Study:
- To review the involvement of non-neuronal cells in migraine pathophysiology.
- To explore non-neuronal cells as potential therapeutic targets for migraine.
Main Methods:
- Review of preclinical evidence linking non-neuronal cells to migraine mechanisms.
- Analysis of the role of astrocytes, microglia, satellite glial cells, Schwann cells, macrophages, and mast cells.
- Examination of therapeutic targets including CGRP, PACAP, and PAR2.
Main Results:
- Astrocytes, microglia, and satellite glial cells are implicated in cortical spreading depolarization and trigeminovascular activation.
- Macrophages and mast cells show specific responses to CGRP and neuropeptides, with mast cell therapies in clinical trials.
- Schwann cells and macrophages may be modulated for therapeutic benefit in migraine.
Conclusions:
- Non-neuronal cells are integral to migraine pathophysiology and represent viable therapeutic targets.
- Targeting non-neuronal cells with therapies like CGRP antagonists or PAR2 inhibitors shows potential.
- Future research utilizing advanced strategies could lead to innovative anti-migraine treatments.
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