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Updated: Feb 7, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Biologic therapy is associated with reduced ocular disease in psoriasis: a real-world study
Shoham Kubovsky1,2, Natan Lishinsky-Fischer1,2, Itay Chowers1,2
1Ophthalmology Department, Hadassah Medical Center, Jerusalem, Israel.
Eye (London, England)
|February 5, 2026
Summary
Biologic therapy for psoriasis patients significantly lowers the risk of ocular surface inflammation, including dry eye disease and keratitis. This finding highlights the importance of considering eye health in psoriasis treatment plans.
Area of Science:
- Immunodermatology
- Ophthalmology
- Systemic Immune-Mediated Diseases
Background:
- Psoriasis is a systemic immune-mediated disease with known ocular manifestations.
- Biologic therapies are effective for psoriasis comorbidities but their ocular impact is unclear.
Purpose of the Study:
- To investigate the association between biologic therapy and the risk of ocular disease in patients with psoriasis.
- To assess the impact of biologics on specific ocular outcomes compared to non-biologic systemic treatments.
Main Methods:
- Retrospective cohort study utilizing the TriNetX Global Collaborative Network (>160 million patients).
- Propensity score matching (1:1) of adults with psoriasis initiating biologic vs. non-biologic systemic therapy.
- Assessment of 68 ocular outcomes over 6 to 120 months using proportional hazards models.
Main Results:
- Biologic therapy was associated with a reduced risk of ocular surface and corneal inflammation in psoriasis patients.
- Strongest associations for reduced risk included dry eye disease (HR=0.55), keratitis (HR=0.40), and conjunctivitis (HR=0.71).
- These protective associations were observed from 6 months and persisted up to 10 years; no effect on retinal or vitreous disease was noted.
Conclusions:
- Biologic therapy for psoriasis is linked to a decreased risk of ocular surface disease.
- These findings suggest that ocular health should be a consideration in managing psoriasis patients treated with biologics.
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