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A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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The Liquid Genioplasty: Different Techniques Compared.
Mario Goisis1, Sheila Veronese2, Patricija Kasilovska3
1De Clinic, C.so di Porta Ticinese 68, 20123, Milan, Italy.
Aesthetic Plastic Surgery
|February 5, 2026
Summary
Non-surgical genioplasty effectively corrects chin retrusion. Dermgraft showed superior long-term patient satisfaction compared to hyaluronic acid fillers and standard lipofilling.
Area of Science:
- Facial Plastic Surgery
- Aesthetic Medicine
- Regenerative Medicine
Background:
- Non-surgical genioplasty offers aesthetic improvement for chin retrusion.
- Concerns exist regarding bone resorption and vascular occlusion with some techniques.
- This study evaluates outcomes of various non-surgical chin augmentation methods.
Purpose of the Study:
- To compare the efficacy and patient satisfaction of different non-surgical chin augmentation techniques.
- To assess the long-term results of hyaluronic acid fillers, lipofilling, and personalized lipofilling (Dermgraft).
- To evaluate the impact of pre-treatment shock waves on fat grafting outcomes.
Main Methods:
- Retrospective analysis of 225 patients undergoing non-surgical genioplasty.
- Comparison of hyaluronic acid (HA) filler, lipofilling, and Dermgraft procedures.
- Inclusion of shock wave treatment for a subset of lipofilling patients.
- 12-month follow-up assessing facial angles and patient satisfaction.
Main Results:
- All treatments improved facial angles.
- Hyaluronic acid fillers yielded higher satisfaction at 3 months.
- Dermgraft demonstrated very high patient satisfaction at 1 year.
- Results maintenance varied significantly between treatment groups.
Conclusions:
- Liquid genioplasty is a safe and effective method for correcting chin retrusion.
- Patient satisfaction is high across different non-surgical techniques.
- Long-term results and satisfaction are dependent on the specific product or procedure used.
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