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Related Experiment Video

Updated: Feb 7, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Scheimpflug tomographic changes across the keratoconus spectrum based on the modified Rabinowitz-McDonnell

Seher Köksaldı1, Mustafa Kayabaşı2, Ezgi Karataş1

  • 1Department of Ophthalmology, Faculty of Medicine, Agri Ibrahim Cecen University, Firat Neighborhood, Yeni Universite Street, No: 2, 04100, Agri, Turkey.

European Journal of Medical Research
|February 6, 2026
PubMed
Summary

Scheimpflug tomography reveals progressive corneal changes in keratoconus, with curvature alterations appearing before thinning. This highlights the clinical relevance of curvature-based classification for characterizing keratoconus progression.

Keywords:
KeratoconusKeratoconus suspectModified Rabinowitz-McDonnell criteriaPentacamScheimpflug tomography

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Area of Science:

  • Ophthalmology
  • Corneal Imaging
  • Biomedical Engineering

Background:

  • Keratoconus is a progressive corneal ectasia characterized by thinning and steepening.
  • Accurate classification and characterization of keratoconus stages are crucial for patient management.
  • Scheimpflug tomography offers advanced imaging for detailed corneal analysis.

Purpose of the Study:

  • To analyze spectrum-dependent changes in Scheimpflug tomographic parameters in normal, keratoconus suspect, and keratoconus eyes.
  • To correlate tomographic findings with keratoconus classification using the modified Rabinowitz-McDonnell index.
  • To elucidate the sequence of tomographic alterations in keratoconus development.

Main Methods:

  • Retrospective analysis of 115 eyes from a tertiary ophthalmology clinic.
  • Classification into control (n=37), keratoconus suspect (n=51), and keratoconus (n=27) groups based on the modified Rabinowitz-McDonnell index.
  • Evaluation of Scheimpflug tomographic data including anterior/posterior keratometry, corneal thickness, volume, anterior chamber depth, and pupil diameter.

Main Results:

  • Progressive increase in anterior and posterior corneal curvature from control to keratoconus groups (p<0.001).
  • Significant curvature differences between control and suspect groups, while pachymetry remained comparable until the keratoconus stage.
  • Corneal volume was higher in suspect eyes; anterior chamber depth increased, and pupil diameter decreased in keratoconus eyes.

Conclusions:

  • Scheimpflug tomography demonstrates stage-dependent corneal changes in keratoconus.
  • Corneal curvature alterations precede significant thinning, validating curvature-based classification.
  • Tomographic parameters enhance the characterization of keratoconus across its spectrum.