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Related Experiment Video

Updated: Feb 7, 2026

A Pulmonary Trunk Banding Model of Pressure Overload Induced Right Ventricular Hypertrophy and Failure
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Right Ventricular Hypertrophy: Pathophysiology, Multimodality Imaging, and Clinical Implications.

Gizem Demir1, Özge Özden Kayhan2, Rengin Çetin Güvenç3

  • 1From the Department of Cardiology, Medical Park Hospitals Group, Medical Park Göztepe Hospital, Istanbul, Turkey.

Cardiology in Review
|February 6, 2026
PubMed
Summary

Right ventricular (RV) hypertrophy is a key response to increased afterload. Imaging helps differentiate adaptive from maladaptive RV hypertrophy, crucial for assessing pulmonary hypertension and guiding therapy.

Keywords:
echocardiographyhypertrophymagnetic resonance imagingpulmonary hypertensionright ventricle

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Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Pathophysiology

Background:

  • Right ventricular (RV) hypertrophy is the primary adaptation to increased afterload.
  • This response can be adaptive, maintaining RV function, or maladaptive, leading to RV failure.
  • Myocardial injury and ischemia often promote maladaptive RV hypertrophy.

Purpose of the Study:

  • To review the pathophysiology of RV hypertrophy.
  • To discuss the role of cardiovascular imaging in assessing RV hypertrophy.
  • To highlight the clinical utility of evaluating RV hypertrophy.

Main Methods:

  • Narrative review of existing literature.
  • Focus on multimodality cardiovascular imaging, especially cardiac magnetic resonance imaging (CMR).
  • Characterization of RV mass, volume, and function using imaging modalities.

Main Results:

  • Multimodality imaging distinguishes adaptive from maladaptive RV hypertrophy.
  • CMR provides reference-standard quantification and tissue characterization.
  • RV hypertrophy assessment aids in screening for pulmonary hypertension and risk stratification.

Conclusions:

  • Evaluating RV hypertrophy is critical for clinical management.
  • Imaging plays a vital role in differentiating RV adaptation states.
  • RV hypertrophy assessment can guide therapeutic strategies and risk stratification.