Related Experiment Video

Updated: Feb 7, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.4K

Glycemic Outcomes Following a Missed Premeal Bolus: A Comparative Study of Three Automated Insulin Delivery Systems

Alzbeta Santova1,2, Lukas Plachy1, Vit Neuman1

  • 1Department of Pediatrics, Motol University Hospital and 2nd Faculty of Medicine, Prague, Czech Republic.

Diabetes Technology & Therapeutics
|February 6, 2026
PubMed

Insights

Automated insulin delivery (AID) systems vary in their ability to manage missed mealtime insulin. The MiniMed 780G and Control-IQ systems better controlled post-meal high blood sugar in children with type 1 diabetes compared to CamAPS.

Area of Science:

  • Pediatric Endocrinology
  • Diabetes Technology
  • Metabolic Disorders

Background:

  • Automated insulin delivery (AID) systems are crucial for managing type 1 diabetes (T1D).
  • Missed premeal insulin boluses significantly impair glycemic control in T1D patients using AID.
  • Understanding AID system performance during missed boluses is vital for optimizing therapy.

Purpose of the Study:

  • To compare postprandial glycemic control across three leading AID systems (MiniMed 780G, Tandem Control-IQ, Ypsomed CamAPS) when premeal boluses are omitted in children with T1D.
  • To evaluate the impact of missed boluses on glucose levels and identify system-specific compensatory effects.

Main Methods:

  • A prospective interventional study involving 43 children with T1D using one of three AID systems.
  • Participants consumed standardized 30g and 50g carbohydrate meals without premeal insulin boluses.
  • Postprandial glucose levels, area under the curve (AUC), and continuous glucose monitoring metrics were analyzed over 4 hours.

Main Results:

  • The MiniMed 780G system demonstrated the lowest mean glucose AUC, followed by Control-IQ, and then CamAPS (P < 0.01).
  • Children using CamAPS experienced significantly more time in hyperglycemia (level 2) compared to those on Control-IQ and 780G, particularly after the 50g carbohydrate load (P < 0.001).
  • The MiniMed 780G and Control-IQ systems showed superior efficacy in mitigating postprandial glucose excursions following missed boluses.

Conclusions:

  • Automated insulin delivery systems exhibit distinct capabilities in compensating for omitted premeal insulin boluses.
  • MiniMed 780G and Control-IQ systems offer better protection against postprandial hyperglycemia compared to CamAPS.
  • These findings suggest that MiniMed 780G and Control-IQ may be more suitable for children with T1D who are prone to missing mealtime insulin doses.
Abstract

Keywords:
automated insulin deliveryboluschildren with diabeteshybrid closed loopmissed bolus

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.0K
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

5.8K

Related Concept Videos

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...
758
Comparative Excretory Systems02:24

Comparative Excretory Systems

Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.7K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.4K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.9K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.3K