Research status and molecular mechanisms of disulfidptosis in cardiovascular diseases (Review)

Area of Science:

• Cardiovascular Medicine
• Cell Biology
• Pathogenesis of Disease

Background:

• Cardiovascular diseases (CVDs) are the leading global cause of mortality.
• Cell death pathways play a significant role in the pathogenesis of CVDs.
• Disulfidptosis is an emerging cell death mechanism with potential therapeutic implications.

Purpose of the Study:

• To review the mechanisms of disulfidptosis in key cardiac cell types.
• To explore the role and evidence of disulfidptosis in cardiovascular diseases.
• To discuss potential therapeutic strategies targeting disulfidptosis for CVDs.

Main Methods:

• Literature review of existing research on disulfidptosis.
• Examination of disulfidptosis mechanisms in cardiomyocytes, vascular smooth muscle cells, endothelial cells, and fibroblasts.
• Analysis of current evidence linking disulfidptosis to cardiovascular pathologies.

Main Results:

• Disulfidptosis mechanisms were analyzed across various cardiac cell types.
• Evidence for disulfidptosis involvement in CVD pathogenesis was discussed.
• Potential intervention strategies targeting disulfidptosis were identified.

Conclusions:

• Disulfidptosis represents a promising, yet under-explored, therapeutic target for cardiovascular diseases.
• Further research into disulfidptosis in the cardiovascular field is warranted.
• Targeting disulfidptosis may offer novel perspectives for CVD prevention and treatment.