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Necrotizing enterocolitis in a patient with Microvillous Inclusion Disease: A case report

Inna Spector Cohen1,2, H Golden3, O Kobi1,4

  • 1Pediatric Gastroenterology & Nutrition Institute, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Intestinal Failure (New York, N.Y.)
|February 6, 2026
PubMed
Abstract

Insights

Microvillous Inclusion Disease (MVID), a rare genetic disorder, can present with necrotizing enterocolitis (NEC). This case highlights the importance of careful enteral feeding management in MVID patients to prevent NEC complications.

Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Genetics

Background:

  • Microvillous Inclusion Disease (MVID) is a rare congenital disorder characterized by severe infantile diarrhea, often necessitating long-term parenteral nutrition.
  • MVID arises from MYO5B gene mutations, which impair brush border protein trafficking essential for intestinal function.
  • Necrotizing enterocolitis (NEC) is infrequently associated with MVID, with limited prior case reports.
Keywords:
Microvillous Inclusion DiseaseNecrotizing enterocolitis

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