Vitamin B1 and sepsis: a prospective single-center study

Area of Science:

• Biochemistry and Molecular Biology
• Critical Care Medicine
• Clinical Diagnostics

Background:

• Vitamin B1 (VB1), a vital coenzyme in energy metabolism, has a poorly understood role in sepsis.
• Existing research on VB1's impact on sepsis outcomes is limited, necessitating further investigation.
• Understanding VB1's clinical utility in sepsis is crucial for potential therapeutic interventions.

Purpose of the Study:

• To investigate the association between Vitamin B1 deficiency and sepsis severity.
• To evaluate the potential of Vitamin B1 in mitigating sepsis-induced organ injury.
• To assess the role of Vitamin B1 in sepsis-related coagulation dysfunction.

Main Methods:

• Serum VB1 levels were quantified using ultra-high-performance liquid chromatography-tandem mass spectrometry in 67 patients.
• Patients were categorized into sepsis (n=41) and control (n=26) groups.
• Multivariate logistic regression analyzed VB1 as a sepsis biomarker.

Main Results:

• Sepsis patients exhibited significantly lower serum VB1 levels compared to controls (p < 0.001).
• VB1 deficiency was more prevalent in sepsis patients, while sufficiency was linked to lower sepsis incidence (p < 0.001).
• VB1 levels negatively correlated with inflammatory markers (procalcitonin, D-dimer) and organ injury indicators (creatinine, troponin I).

Conclusions:

• VB1 levels show an inverse relationship with key inflammatory biomarkers in sepsis.
• Lower VB1 concentration is independently associated with a higher prevalence of sepsis.
• VB1 may serve as a potential biomarker for sepsis severity and a target for therapeutic strategies.