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Updated: Feb 7, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Unveiling the Uncommon: A Rare IgE-Mediated Presentation of Multiple Drug Hypersensitivity Syndrome
Ana Vitória Soares1,2, Diogo Mota1, Daniela Brandão Abreu1
1Allergy and Clinical Immunology Department, Centro Hospitalar Universitário São João, Porto, PRT.
Abstract:
Multiple drug hypersensitivity syndrome (MDHS) is characterized by hypersensitivity reactions to two or more unrelated drugs. Although it is commonly associated with delayed reactions, we report a rare case of immediate IgE-mediated MDHS in a 30-year-old female who reacted to levofloxacin and ibuprofen. Both reactions were confirmed through drug challenges, while acetylsalicylic acid was tolerated, excluding COX-1 cross-reactivity. This case highlights the importance of recognizing IgE-mediated MDHS and performing thorough allergy diagnostic workups to ensure accurate management and patient safety.
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