Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

580
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
580
Accelerators01:17

Accelerators

291
Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
291
Proteomics01:33

Proteomics

9.8K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.8K
Aging01:26

Aging

713
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
713
Average Acceleration01:30

Average Acceleration

14.0K
The importance of understanding acceleration spans our day-to-day experiences, as well as the vast reaches of outer space and the tiny world of subatomic physics. In everyday conversation, to accelerate means to speed up. For instance, we are familiar with the acceleration of our car; the harder we apply our foot to the gas pedal, the faster we accelerate. The greater the acceleration, the greater the change in velocity over a given time. Acceleration is widely seen in experimental physics. In...
14.0K
Instantaneous Acceleration01:16

Instantaneous Acceleration

23.2K
Acceleration is in the direction of the change in velocity, but it is not always in the direction of motion. When an object slows down, its acceleration is opposite to the direction of its motion. Although commonly referred to as deceleration, this causes confusion in our analysis as deceleration is not a vector, and does not point to a specific direction with respect to a coordinate system. Therefore, the term deceleration is not used. For example, when a subway train slows down, it...
23.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological aging clocks in health and disease.

Nature medicine·2026
Same author

Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.

Stroke·2026
Same author

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026
Same author

Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study.

Neurology·2026
Same author

Diversion of Arginine's dietary metabolic fate in proteinuric kidney disease.

Research square·2026
Same author

Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts.

Nature aging·2026

Related Experiment Video

Updated: Feb 7, 2026

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.3K

Accelerated multi-organ proteomic aging is detectable decades before dementia onset.

Fangyu Liu, Wenyu Zhou, Aditya Surapaneni

    Medrxiv : the Preprint Server for Health Sciences
    |February 6, 2026
    PubMed
    Summary

    Midlife organ aging pace, not just current age, predicts future dementia risk and neurodegeneration. Advanced multi-organ aging, particularly brain and heart/muscle, synergistically increases dementia risk.

    More Related Videos

    Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
    10:58

    Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

    Published on: August 29, 2013

    11.7K
    The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
    06:23

    The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

    Published on: October 13, 2016

    33.9K

    Related Experiment Videos

    Last Updated: Feb 7, 2026

    Using Retinal Imaging to Study Dementia
    09:17

    Using Retinal Imaging to Study Dementia

    Published on: November 6, 2017

    22.3K
    Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
    10:58

    Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model

    Published on: August 29, 2013

    11.7K
    The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
    06:23

    The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

    Published on: October 13, 2016

    33.9K

    Area of Science:

    • Gerontology
    • Neuroscience
    • Proteomics

    Background:

    • Proteomics research links organ aging to dementia risk.
    • Longitudinal studies are needed to understand the temporal relationship between organ aging and neurodegeneration.

    Purpose of the Study:

    • To investigate the association between midlife organ age and the pace of organ aging with future dementia risk and neurodegeneration.
    • To explore the synergistic effects of multi-organ aging on dementia risk.
    • To identify proteins influencing the pace of multi-decade brain aging.

    Main Methods:

    • Longitudinal study design.
    • Proteome-wide analysis in midlife.
    • Mendelian randomization.

    Main Results:

    • Midlife organ age and its pace over decades predict dementia risk and neurodegeneration, independent of late-life organ age.
    • Advanced multi-organ aging, especially combined brain and heart/muscle aging, synergistically increases dementia risk.
    • Identified non-brain proteins, including TNFRSF1B, GM2A, and LSAMP, associated with the pace of brain aging, with TNFRSF1B causally linked to accelerated aging in multiple organs.

    Conclusions:

    • The pace of organ aging from midlife is a critical determinant of future dementia risk.
    • Multi-organ aging, particularly brain and cardiovascular/muscle systems, poses a synergistic risk for dementia.
    • Specific proteins may serve as therapeutic targets for mitigating age-related cognitive decline and neurodegeneration.