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Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
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Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions.

Ehsan Pashay Ahi1

  • 1Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences University of Helsinki Helsinki Finland.

Ecology and Evolution
|February 6, 2026
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Summary

Epitranscriptomic modifications, like N6-methyladenosine (m⁶A), regulate cellular dormancy by controlling mRNA stability and translation. These RNA marks act as a molecular interface, fine-tuning cellular transitions between active and paused states.

Keywords:
N6‐methyladenosine (m6A)RNA chemical modificationsdormancyeco‐evolutionary adaptationepitranscriptomics

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Dormancy is a conserved strategy for stress survival and developmental arrest.
  • Transcriptional regulation is well-studied, but post-transcriptional control is gaining attention.
  • Epitranscriptomic modifications offer rapid, reversible gene expression control.

Purpose of the Study:

  • To propose a unifying model where epitranscriptomic modifications regulate cellular dormancy.
  • To explore the role of RNA modifications in establishing, maintaining, and exiting dormancy.
  • To highlight the intersection of RNA regulation and cellular dormancy.

Main Methods:

  • Literature review and synthesis of existing evidence.
  • Analysis of data from plant seeds, microbial persisters, stem cells, and dormant cancer cells.
  • Development of a conceptual model for epitranscriptomic regulation of dormancy.

Main Results:

  • Specific RNA marks, such as N6-methyladenosine (m⁶A), influence mRNA stability, translation, and localization.
  • RNA modifications act as a molecular interface between environmental signals and cellular responses.
  • A model is presented where epitranscriptomics modulates dormancy transitions across taxa.

Conclusions:

  • Epitranscriptomic modifications are crucial for regulating cellular dormancy.
  • RNA modifications provide an underexplored regulatory layer in cellular inactive states.
  • Further research is needed to understand the mechanistic insights and evolutionary parallels.