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Updated: Jul 2, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs

Honglei Zhang1,2, Yangjian Liu2, Jingxuan Ma1

  • 1Beijing Youcare Kechuang Pharmaceutical Technology Co., Ltd., Beijing 100176, P.R. China.

Molecular Therapy. Nucleic Acids
|February 6, 2026
PubMed
Abstract

Keywords:
2′-ribose-modified nucleotidesMT: Oligonucleotides: Therapies and ApplicationsPCSK9 suppressionmononucleotide synthesisreducing off-target effectssiRNA

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