Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Dementia

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....

Relationship Formation

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...

What is Metabolism?

What is Metabolism?

Ending Relationships

Ending Relationships

The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...

Kinetic Molecular Theory and Gas Laws Explain Properties of Gas Molecules

Kinetic Molecular Theory and Gas Laws Explain Properties of Gas Molecules

The test of the kinetic molecular theory (KMT) and its postulates is its ability to explain and describe the behavior of a gas. The various gas laws (Boyle’s, Charles’s, Gay-Lussac’s, Avogadro’s, and Dalton’s laws) can be derived from the assumptions of the KMT, which have led chemists to believe that the assumptions of the theory accurately represent the properties of gas molecules.

Glucose Homeostasis: Regulation of Blood Glucose

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Latent Space Projections and Atlases, a Cautionary Tale in Deep Neuroimaging using Autoencoders.

International journal of neural systems·2026

Same author

An explainable framework for the relationship between dementia and metabolism patterns.

NeuroImage·2026

Same author

Statistical agnostic regression: A machine learning method to validate regression models.

Journal of advanced research·2025

Same author

Nonlinear Weighting Ensemble Learning Model to Diagnose Parkinson's Disease Using Multimodal Data.

International journal of neural systems·2023

Same author

Prenatal diagnosis and postnatal outcome of fetal congenital knee dislocation: systematic review of literature.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023

Same author

Reoperation on an Implant-Supported Restoration in the Maxillary Anterior Region to Correct a Complex Aesthetic Deficit.

Case reports in dentistry·2022

Search research articles

Related Experiment Video

Updated: Feb 7, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

An Explainable Framework for the Relationship between Dementia and Metabolism Patterns.

C Vázquez-García¹, F J Martínez-Murcia¹, F Segovia Román¹

¹Department of Signal Processing and Biomedical Applications, University of Granada, Granada 18071, Spain.

|February 6, 2026

Summary

This summary is machine-generated.

This study introduces a semi-supervised Variational Autoencoder (VAE) framework to analyze neuroimaging data for neurodegenerative diseases. The model aligns latent spaces with cognitive scores, revealing key brain region metabolism changes in Alzheimer's disease progression.

Keywords:

ADNI Alzheimer Computational Neuroscience PET Variational Autoencoder

More Related Videos

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

Related Experiment Videos

Last Updated: Feb 7, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

Area of Science:

Neuroscience
Medical Imaging
Machine Learning

Background:

High-dimensional neuroimaging data poses challenges for studying neurodegenerative diseases due to complex relationships.
Variational Autoencoders (VAEs) offer a method to reduce data dimensionality and extract relevant features.

Purpose of the Study:

To develop a semi-supervised VAE framework for neuroimaging analysis in neurodegenerative diseases.
To align latent representations with clinical or biomarker measures of disease progression, such as cognitive scores.

Main Methods:

Implemented a semi-supervised VAE with a flexible similarity regularization term.
Utilized PET scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset.
Guided the first latent dimension to correlate with a cognitive score.

Main Results:

Generated average reconstructions reflecting cognitive impairment levels.
Identified reduced metabolism in the hippocampus and key Resting State Networks (Default Mode, Central Executive).
Latent variables captured confounds like inter-subject variability and site effects.

Conclusions:

The VAE framework effectively extracts Alzheimer's disease-related patterns aligned with biomarkers.
The approach provides an interpretable and adaptable tool for studying neurodegenerative disease progression.
Demonstrated utility in linking neuroimaging features to cognitive decline.