Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

Jasper H A Schuurmans1, Stefan D A Zondag2, Arnab Chaudhuri3

  • 1Flow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), Universiteit van Amsterdam (UvA), 1098 XH Amsterdam, The Netherlands.

ACS Central Science
|February 6, 2026
PubMed
Summary

Mixing is vital for chemical reactions, ensuring reactants interact effectively. Proper mixing is crucial for reproducible, scalable, and safe organic synthesis, even in seemingly agitation-insensitive reactions.

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