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Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry
Jasper H A Schuurmans1, Stefan D A Zondag2, Arnab Chaudhuri3
1Flow Chemistry Group, Van't Hoff Institute for Molecular Sciences (HIMS), Universiteit van Amsterdam (UvA), 1098 XH Amsterdam, The Netherlands.
Abstract:
Mixing is essential in chemical processes, ensuring the proximity and interaction of reactants. Recent reports suggest stirring may minimally affect some solution-phase organic reactions, but this oversimplifies mixing's complexity. We discuss its principles, relevance to organic synthesis, and practical considerations for reproducibility and safety. Even if some reactions seem agitation-insensitive, mixing remains crucial for reproducibility, scalability, and industrial applications.
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