Characterisation of oncology EHR-derived real-world data in the UK, Germany, and Japan

Oncology real-world data (RWD) from electronic health records (EHRs) can generate real-world evidence crucial for clinical and policy decisions. However, challenges in accessing and harmonising data across countries limit its global applicability. Flatiron Health has developed oncology EHR-derived RWD datasets in the UK, Germany, and Japan, integrating these with its United States database to support multinational studies. This paper outlines the methods, aligned with the ISPOR EHR-derived data SUITABILITY checklist, to ensure the trustworthiness, reliability, and relevance of these datasets.