Related Experiment Video
Updated: Feb 7, 2026
07:22
Arthroscopic Management of Massive Irreparable Rotator Cuff Tears: Whole Rotator Cable Reconstruction Using Proximal Biceps Tendon Autograft
Published on: June 6, 2025
682
Atelocollagen Improves Bone-to-Tendon Interface Healing in a Rabbit Model of Chronic Rotator Cuff Tear Compared with
Jian Han1,2, Zhan-Feng Zhang2, Shen-Yun Fang2
1Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Clinics in Orthopedic Surgery
|February 6, 2026
Summary
Atelocollagen (ATC) significantly enhanced bone-to-tendon healing in rabbit rotator cuff tears compared to polydeoxyribonucleotide (PDRN) and saline. ATC promoted better tissue regeneration and stronger repair, offering a promising therapeutic option.
Area of Science:
- Orthopedic surgery
- Biomaterials science
- Regenerative medicine
Background:
- Rotator cuff healing presents challenges in agent selection.
- Polydeoxyribonucleotide (PDRN) and atelocollagen (ATC) are available but their comparative efficacy is unclear.
- Direct comparisons of PDRN and ATC for rotator cuff repair are lacking.
Purpose of the Study:
- To compare the efficacy of PDRN and ATC in promoting bone-to-tendon interface (BTI) healing.
- To evaluate these agents in a rabbit chronic rotator cuff tear (RCT) model.
Main Methods:
- A chronic RCT model was established in 48 rabbits.
- Rabbits were divided into three groups: saline, PDRN, and ATC.
- Analyses included genetic, immunofluorescence, histologic, and biomechanical assessments at 4 and 12 weeks post-repair.
Main Results:
- ATC enhanced mRNA expression of collagen type I and aggrecan at 4 weeks.
- At 12 weeks, ATC showed improved collagen organization, mature BTI, and greater fibrocartilage formation.
- ATC group exhibited significantly higher load-to-failure strength (40.4 N/kg) versus saline (26.7 N/kg) and PDRN (32.8 N/kg).
Conclusions:
- Atelocollagen (ATC) demonstrated superior efficacy in promoting bone-to-tendon interface healing.
- ATC facilitated better tissue regeneration and biomechanical strength in a chronic rotator cuff tear model.
- ATC represents a promising agent for enhancing rotator cuff repair outcomes.
Keywords:
AtelocollagenBone-to-tendon interfaceChronic rotator cuff tearPolydeoxyribonucleotideRotator cuff healingMore Related Videos
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