Related Experiment Video
Updated: Feb 7, 2026

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
Conversion Surgery after Chemotherapy in a Stage IV BRAF V600E-Mutated Laterally Spreading Tumor With Neuroendocrine
Reona Kawamura1, Naoya Toyoshima1, Masau Sekiguchi1
1Endoscopy Division National Cancer Center Hospital Tokyo Japan.
None:
We report a rare case of a BRAF V600E-mutated laterally spreading tumor, granular type (LST-G), with a neuroendocrine carcinoma (NEC) component in a patient with stage IV colorectal cancer. The patient presented with multiple lymph nodes and liver metastases. Following systemic chemotherapy, significant regression of both the primary lesion and metastases was achieved, enabling successful conversion surgery. Postoperative pathological analysis post-surgery revealed only well-differentiated tubular adenocarcinoma, with complete disappearance of the NEC component. Molecular testing confirmed the persistence of the BRAF V600E mutation. The patient remains recurrence-free two years after surgery. This case highlights the potential for conversion surgery in stage IV BRAF-mutated colorectal cancer with NEC.
More Related Videos
Related Concept Videos
Mutations
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Gene Conversion
Gene Conversion
Spreading of Chromatin Modifications
Writers
The writer...
Viral Mutations

