Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Applications of GIS: Disaster Management and Emergency Response01:29

Applications of GIS: Disaster Management and Emergency Response

529
Geographic Information System (GIS) technology is essential for risk identification, action prioritization, and resource optimization in critical situations like flooding and earthquakes. By integrating spatial and demographic data, GIS provides a comprehensive framework for emergency response.GIS integrates data layers, like rainfall intensity, topography, elevation profiles, and river levels, to model high-risk flood zones. These layers assess areas susceptible to flooding based on their...
529
Emerging Adulthood01:27

Emerging Adulthood

700
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
700
Self-Concept01:19

Self-Concept

1.7K
Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
Infancy and Emerging Recognition
During infancy, self-concept is virtually nonexistent. Babies do not distinguish themselves as separate entities and often mistake their...
1.7K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

11.0K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
Concepts and Prototypes01:24

Concepts and Prototypes

548
The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
The brain organizes this information using concepts, which are mental categories grouping linguistic data,...
548
Formula Mass and Mole Concepts of Compounds02:56

Formula Mass and Mole Concepts of Compounds

81.7K
Formula Mass of Covalent Compounds
81.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term treatment of atopic dermatitis with roflumilast cream 0.15% in patients aged 6 years or older (INTEGUMENT-OLE clinical study): a plain language summary.

The Journal of dermatological treatment·2026
Same author

Roflumilast foam versus vehicle foam for seborrheic dermatitis (STRATUM clinical study): a plain language summary.

The Journal of dermatological treatment·2026
Same author

Durability of response to icotrokinra for high-impact site psoriasis: 1-year ICONIC-TOTAL findings.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

A Review of the Effects of Lifestyle Factors on Skin Aging.

American journal of lifestyle medicine·2026
Same author

Considerations for Genital Psoriasis Care Across Age Groups: A Modified Delphi Consensus Initiative from the Genital Psoriasis Wellness Consortium.

American journal of clinical dermatology·2026
Same author

High Curl Pattern Hair and Scalp Care Considerations to Mitigate Seborrheic Dermatitis.

Journal of cosmetic dermatology·2026
Same journal

Severe Nail Psoriasis and Early Psoriatic Arthritis: Illustrative Cases Confirming That Severity of Disease Is Not Solely Dependent on the Extent of Body Surface Area.

The Journal of clinical and aesthetic dermatology·2026
Same journal

Pipeline of Devices and Aesthetics: What Is Left?

The Journal of clinical and aesthetic dermatology·2026
Same journal

An Analysis of Thyrotropin Levels in Patients With Nonscarring Alopecia: A Single-Center Retrospective Comparative Study.

The Journal of clinical and aesthetic dermatology·2026
Same journal

Exploring the Therapeutic Potential of Topical Honey in Atopic Dermatitis.

The Journal of clinical and aesthetic dermatology·2026
Same journal

Plant Exosome Injection: A New Boost for Postlaser Vascular Repair.

The Journal of clinical and aesthetic dermatology·2026
Same journal

The Treatment of Perioral (Periorificial) Dermatitis With Topical Roflumilast 0.3% Cream: An Illustrative Case Study With Rapid Onset and Prolonged Remission.

The Journal of clinical and aesthetic dermatology·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.8K

PDE4 Inhibitor-Responsive Dermatoses: An Emerging Concept in Dermatology.

Courtney A Chau1, Hilary E Baldwin2, James Q Del Rosso3

  • 1Ms. Chau is with the Icahn School of Medicine at Mount Sinai in New York, New York.

The Journal of Clinical and Aesthetic Dermatology
|February 6, 2026
PubMed
Summary
This summary is machine-generated.

Phosphodiesterase 4 (PDE4) inhibitors offer a new treatment approach for various inflammatory skin conditions. These drugs target key pathways, suggesting a new category of "PDE4 inhibitor-responsive dermatoses."

Keywords:
PDE4 inhibitor-responsive dermatosesSteroid-responsive dermatosesapremilastcrisaborolephosphodiesterase 4 inhibitionroflumilast

More Related Videos

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
03:29

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms

Published on: May 31, 2024

963
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.3K

Related Experiment Videos

Last Updated: Feb 7, 2026

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
09:27

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.8K
Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
03:29

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms

Published on: May 31, 2024

963
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

31.3K

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Inflammatory skin conditions often share underlying mechanistic pathways.
  • The concept of 'steroid-responsive dermatoses' highlights shared therapeutic targets.
  • Phosphodiesterase 4 (PDE4) enzyme inhibition is a promising strategy for interrupting inflammatory pathways in skin diseases.

Purpose of the Study:

  • To review clinical evidence supporting the concept of 'PDE4 inhibitor-responsive dermatoses.'
  • To propose PDE4 inhibition as a complementary therapeutic pathway for multiple dermatologic conditions.

Main Methods:

  • Review of clinical trial data for approved PDE4 inhibitors.
  • Analysis of efficacy and safety profiles of PDE4 inhibitors in dermatologic conditions.

Main Results:

  • PDE4 inhibitors (apremilast, crisaborole, roflumilast) show robust efficacy and safety.
  • These agents are FDA-approved for atopic dermatitis, psoriasis, and seborrheic dermatitis.
  • Evidence supports PDE4 inhibition as a unifying therapeutic strategy.

Conclusions:

  • PDE4 inhibition represents a significant advancement in treating inflammatory skin diseases.
  • The concept of 'PDE4 inhibitor-responsive dermatoses' is emerging.
  • Targeting PDE4 offers a versatile approach to managing diverse dermatologic conditions.