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The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging
Glynis Ablon1, Jyotsna Paturi2, Franck Juchaux3
1Dr. Ablon is with the Ablon Skin Institute and Research Center in Manhattan Beach, California.
Objective:
With advances in aesthetic procedures, best practices for postprocedure care to support immediate healing and augment efficacy are still without consensus. A postprocedure formula containing hydroxypropyl tetrahydropyrantriol (HPT) and niacinamide (NAM) has been developed. This study evaluated the functional benefits and clinical efficacy of pairing HPT/NAM formula with nonablative fractional laser treatment.
Methods:
The functional benefits of HPT/NAM were explored using 2D cellular models, reconstructed skin equivalents, and ex vivo skin models. The clinical efficacy of a HPT/NAM formula vs. a clinical control (Aquaphor Healing Ointment) was investigated through a randomized, double-blind, split-face, multicenter, multiethnic study with a White and a Northeast Asian panel. The investigative products were randomly assigned to one side of the face following a single full-face fractional nonablative laser procedure, and the products were applied twice daily for 56 days.
Results:
In vitro testing showed that the HPT/NAM combination decreased the secretion of prostaglandin E2 (PGE2), encouraged the production of glycosaminoglycan, α-smooth muscle actin, and various angiogenic growth factors. In both panels, the HPT/NAM formula demonstrated significant improvement vs. the clinical control for key anti-aging parameters such as fine lines, crow's feet wrinkles, skin roughness, and overall healthy appearance over the course of 56 days.
Limitations:
This study only investigated the pairing of HPT/NAM formula with nonablative laser treatment.
Conclusion:
This study demonstrated comparable healing benefits to the clinical control along with augmented skin resurfacing benefits with HPT/NAM use following a nonablative fractional laser treatment.
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