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Updated: Feb 7, 2026

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
Published on: April 20, 2021
EUS-based shear wave elastography of the spleen for detection of clinically significant portal hypertension
Jad P AbiMansour1, Jerry Yung-Lun Chin1, Eric J Vargas1
1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Background And Aims:
A measurement of spleen stiffness has been demonstrated to improve the detection of clinically significant portal hypertension (CSPH). In this study, we evaluated the performance of EUS-guided shear wave elastography (EUS-SWE) for detecting CSPH.
Methods:
EUS-SWE measurements of the spleen were compared between patients with and without CSPH. Receiver-operating characteristic curve analysis was performed and quantified by the area under the receiver-operating characteristic curve (AUROC).
Results:
Of 142 patients with EUS-SWE spleen measurements, 13 (9.2%) had CSPH and 129 (90.8%) did not. Patients with CSPH had a significantly higher mean spleen stiffness (37.6 ± 8.5 kPA vs 29.1 ± 9.9 kPA, P = .003). The AUROC was .74.
Conclusions:
SWE is a promising technology that can readily be incorporated into standard EUS examination for assessment of portal hypertension.
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