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Updated: Feb 7, 2026

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
Published on: October 19, 2018
Utilization of methylene blue-based submucosal injection to identify residual neuroendocrine tumor in the colon after
Weina Jing1,2, Yuxiang Chen1,2, Kai Deng1,2
1Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Abstract:
A woman underwent colonoscopy with biopsy sampling that revealed a tiny neuroendocrine tumor (NET) about 5 cm from the anus. After several months, the biopsy sampling site healed completely, making the identification of the residual NET difficult. The specific location of the lesion could not be confirmed even under magnifying endoscopy and EUS. When a higher concentration of methylene blue was injected into the submucosa, the residual lesion was exposed. The endoscopist then inferred the likely location of the lesion on magnifying endoscopy on the basis of the marker and the location of the lesion after injection of methylene blue. Finally, the residual lesion was successfully removed, and the postoperative pathology confirmed that the resected lesion was a residual NET measuring 1.5 × .5 mm.
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