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Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos
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Multidrug-resistant Pseudomonas aeruginosa infections: current status, challenges, and prospects of phage therapy

Bo Yan1,2, Can Yan1,2, Yafang Ding1,2

  • 1Affiliated Hospital of Jinggangshan University, Ji'an, China.

Frontiers in Microbiology
|February 6, 2026
PubMed

Insights

Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant Pseudomonas aeruginosa infections. This approach utilizes bacteriophages to combat resistant bacteria, addressing a critical public health challenge.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biotechnology

Background:

  • Multidrug-resistant bacterial infections, particularly from Pseudomonas aeruginosa (MDR-PA), pose a significant global health threat.
  • MDR-PA infections are associated with high mortality rates (up to 40%) due to virulence factors and biofilm formation.
  • Conventional antibiotic treatments are becoming less effective against MDR-PA, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review recent advancements in phage therapy for multidrug-resistant Pseudomonas aeruginosa.
  • To synthesize current clinical applications, therapeutic approaches, and emerging technologies in phage therapy.
  • To explore resistance mechanisms and propose counterstrategies for effective phage therapy.

Main Methods:

  • Comprehensive literature review of recent studies on phage therapy against MDR-PA.
  • Analysis of clinical applications, therapeutic strategies, and technological platforms.
  • Examination of bacterial resistance mechanisms and development of novel counterstrategies.

Main Results:

  • Phage therapy demonstrates precise bactericidal activity and high host biosafety as an alternative to antibiotics.
  • Recent advancements include optimized phage-antibiotic synergy, phage genome engineering, and adaptive therapeutic frameworks.
  • Understanding resistance mechanisms is crucial for developing effective counterstrategies.

Conclusions:

  • Phage therapy is a viable and evolving alternative for combating multidrug-resistant Pseudomonas aeruginosa infections.
  • Innovative strategies like phage-antibiotic synergy and genome engineering are key to overcoming resistance.
  • Further research and development are essential for the clinical translation of phage therapy.
Keywords:
MDR-PAantimicrobial resistancebacteriophageinfectionstherapy

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