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Related Experiment Video

Updated: Feb 7, 2026

Molecular Evolution of the Tre Recombinase
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Genetic evolution and codon usage mode of SFTSV.

Yuhan Zhang1,2, Li Hu1, Chao Li1

  • 1Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Frontiers in Microbiology
|February 6, 2026
PubMed
Summary

Severe fever with thrombocytopenia syndrome virus (SFTSV) shows increasing genetic diversity through recombination and distinct genotypes. Natural selection predominantly shapes its codon usage, offering insights for disease control and vaccine development.

Keywords:
SFTSVcodon usage biasevolutionreassortmentrecombination

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Area of Science:

  • * Virology and Molecular Evolution
  • * Public Health and Infectious Diseases

Background:

  • * Severe fever with thrombocytopenia syndrome virus (SFTSV), identified in 2009, is a growing public health concern in China.
  • * Limited understanding of SFTSV molecular evolution, genetic characterization, and codon usage bias hinders effective control.

Purpose of the Study:

  • * To genetically characterize SFTSV strains from recent cases.
  • * To investigate the molecular evolution, including recombination and codon usage patterns, of SFTSV.

Main Methods:

  • * Analysis of blood samples from suspected SFTS cases.
  • * Whole-genome sequencing and phylogenetic analysis for genotype classification.
  • * Identification of recombination events using RDP4.
  • * Codon usage bias investigation via ENC-plot, PR2 analysis, and neutral evolution analysis.

Main Results:

  • * SFTSV strains belonged to genotypes C3 and C1.
  • * 99 potential recombination events were identified across 89 viral strains.
  • * SFTSV exhibits weak codon usage bias, influenced by both natural selection and mutational pressure.
  • * Natural selection is the primary driver of codon usage in four SFTSV genes.

Conclusions:

  • * SFTSV demonstrates significant evolutionary diversity driven by recombination and multiple genotypes.
  • * Understanding codon usage patterns, influenced by natural selection, is crucial for SFTSV surveillance and vaccine design.
  • * Findings support enhanced strategies for SFTSV disease control and prevention.