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Calcium interaction with Nav1.5 via FGF12A and CaM binding

Lucy Woodbury1, Anna Li1, Paweorn Angsutararux2

  • 1Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA.

Biorxiv : the Preprint Server for Biology
|February 6, 2026
PubMed
Summary

Calmodulin (CaM) and fibroblast growth factor 12A (FGF12A) interact with cardiac sodium channels (Nav1.5) in a calcium-dependent manner. This interaction modulates Nav1.5 inactivation, impacting cardiac action potentials.

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