Aging macaques bridge the translational gap in perivascular space biology
William A Liguore1, Daniel L Schwartz2,3, Juan Piantino4
1Oregon National Primate Research Center.
Biorxiv : the Preprint Server for Biology
|February 6, 2026
Abstract
None:
The prevalence of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5-28 years of age demonstrated a robust association between age and PVS burden, with an anatomical distribution paralleling that of humans. Preliminary ex vivo validation confirmed that the MRI-detected tubular structures correspond to perivascular spaces. These findings establish the rhesus macaque as a tractable model for understanding the role of perivascular dysfunction in age-related brain vulnerability.
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