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Aging macaques bridge the translational gap in perivascular space biology

William A Liguore1, Daniel L Schwartz2,3, Juan Piantino4

  • 1Oregon National Primate Research Center.

Biorxiv : the Preprint Server for Biology
|February 6, 2026
PubMed

Insights

The prevalence of MRI-visible perivascular spaces (PVS) increases with age in rhesus macaques. This study validates macaques as a model for studying age-related brain changes and perivascular dysfunction.

Area of Science:

  • Neuroimaging
  • Comparative Anatomy
  • Aging Research

Background:

  • Perivascular spaces (PVS) are fluid-filled spaces surrounding blood vessels in the brain.
  • Age-related changes in PVS are implicated in various neurological conditions.
  • Understanding PVS in aging models is crucial for human brain health research.

Purpose of the Study:

  • To investigate the age-dependency of MRI-visible perivascular spaces (PVS) in rhesus macaques.
  • To establish the rhesus macaque as a model for studying age-related brain vulnerability and PVS dysfunction.

Main Methods:

  • Utilized magnetic resonance imaging (MRI) for PVS visualization.
  • Employed automated quantification techniques to assess PVS burden.
  • Included a cohort of 94 male and female rhesus macaques aged 5-28 years.
  • Performed preliminary ex vivo validation to confirm MRI-detected structures.

Main Results:

  • Demonstrated a significant age-dependent increase in the prevalence and burden of MR-visible PVS in rhesus macaques.
  • Observed an anatomical distribution of PVS that parallels findings in human brains.
  • Confirmed that MRI-detected tubular structures accurately represent perivascular spaces.

Conclusions:

  • Rhesus macaques exhibit age-related PVS changes similar to humans.
  • The rhesus macaque is a suitable model for investigating the role of PVS dysfunction in aging brains.
  • Findings support the use of this model to explore age-related brain vulnerability.

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