Memory erasure by dopamine-gated retrospective learning

Huijeong Jeong1, Leo Zsembik2,3, Farah Farouq1,3

  • 1Department of Neurology, University of California, San Francisco, CA, USA.

Summary

True memory erasure, unlike standard extinction, is achieved by presenting outcomes without cues. This "retrospective extinction" requires mesolimbic dopamine, offering new strategies to erase maladaptive memories and prevent relapse.

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