Related Experiment Video

Updated: Feb 7, 2026

De Novo Generation of Somatic Stem Cells by YAP/TAZ
13:05

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Published on: May 7, 2018

9.6K

Fibroblast-specific Deletion of Yap/Taz Impairs Mouse Postnatal Dermal Development by Suppressing Collagen Production

Alexandre, Ava J Kim, Kirk C Hansen

    Biorxiv : the Preprint Server for Biology
    |February 6, 2026
    PubMed

    Insights

    The Hippo pathway effectors YAP and TAZ are crucial for skin dermal development and extracellular matrix (ECM) homeostasis. Their absence impairs collagen production, impacting skin structure and regeneration potential.

    Area of Science:

    • Cell Biology
    • Dermatology
    • Developmental Biology

    Background:

    • The Hippo pathway, involving YAP and TAZ, regulates cell growth and tissue homeostasis.
    • While YAP/TAZ roles in epithelia and cancer are known, their function in dermal fibroblast ECM regulation is unclear.

    Purpose of the Study:

    • To investigate the role of YAP/TAZ in postnatal mouse skin dermis development.
    • To understand YAP/TAZ involvement in dermal fibroblast extracellular matrix (ECM) homeostasis.

    Main Methods:

    • Postnatal deletion of YAP/TAZ in mouse dermal fibroblasts.
    • Analysis of collagen synthesis, deposition, and fibroblast proliferation.
    • RNA-sequencing, spatial transcriptomics, and proteomics.

    Main Results:

    • YAP/TAZ deletion impaired dermal maturation, reducing collagen synthesis and deposition.
    • Fibroblasts from knockout mice showed reduced proliferation and target gene expression.
    • Downregulation of key matrisome genes, including type I and III collagens, was observed.

    Conclusions:

    • YAP/TAZ are essential regulators of dermal ECM homeostasis during postnatal skin development.
    • These findings suggest YAP/TAZ as potential therapeutic targets for skin regeneration, fibrosis, and aging.

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