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Updated: Feb 7, 2026

Intraductal Delivery to the Rabbit Mammary Gland
Published on: March 9, 2017
Mitochondria-nucleus communication dictates progressive versus bimodal aging of the mammary gland
Edmund Charles Jenkins1, Mrittika Chattopadhyay1, Thelma Mashaka1
1Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, Department of Medicine, Division of Hematology/ Oncology, New York, 10029, NY, USA.
Abstract:
Non-linear aging, identified through oscillations in human plasma proteomics around 44 and 60, is postulated to contribute to the onset of diseases. Incidence of breast cancer follows such bimodal pattern. We show that mitochondria-nucleus matching in mice results in two mammary gland aging patterns, including a bimodal pattern associated with susceptibility to mammary tumor and that this bimodal signature is enriched in breast cancer patients diagnosed at 45 and 65.
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