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Head and Neck Sarcoma Assessor (HaNSA) for treatment decisions using real-world data
M Y S See1, J J N Goh2, C E Low3
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
ESMO Real World Data and Digital Oncology
|February 6, 2026
Summary
This study analyzed head and neck sarcomas (HNS) in Asians, finding radiotherapy-associated sarcomas impact outcomes. A new prognostic calculator aids in predicting overall survival for HNS patients.
Area of Science:
- Oncology
- Cancer Research
- Epidemiology
Background:
- Head and neck sarcomas (HNS) are rare, diverse cancers with poor survival.
- HNS are understudied in Asian populations, limiting clinical trial viability.
- Accurate histological typing in real-world Asian cohorts is crucial for understanding HNS.
Purpose of the Study:
- To analyze risk factors for overall survival (OS) in Asian patients with head and neck sarcomas.
- To develop a prognostic calculator for predicting OS in HNS patients using real-world data.
Main Methods:
- Retrospective cohort study of 275 patients with histologically confirmed HNS (1985-2023).
- Multivariate Cox regression analysis for OS risk factors.
- Parametric time-to-event modeling to create a prognostic calculator.
Main Results:
- The 5-year OS was 43.2%.
- Radiotherapy-associated sarcomas occurred in 11.3% of patients, linked to poorer prognosis.
- Microscopically negative (R0) resection margins significantly improved OS; R1 resections also showed benefit in specific cases, especially with high-dose radiotherapy.
Conclusions:
- Presents the largest Asian HNS cohort, revealing poor outcomes partly due to radiotherapy-associated disease.
- A novel prognostic calculator demonstrates the utility of curated real-world data for predicting OS in rare cancers like HNS.
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