Microwave-Assisted One-Pot Synthetic Pathways for Pyrido[2,3-d]imidazole Derivatives

Herein, we report efficient microwave-assisted one-pot protocols, enabling the efficient synthesis of a broad scope of functionalized pyrido[2,3-d]imidazoles. The developed methodologies allow obtaining target compounds using cheap reagents and catalysts, in very short reaction times, and perform three-step reactions in the same vessel without the need of intermediate isolation. The obtained pyridoimidazoles equipped with alkyl, alkoxy, hydroxy, halogen, acyl, and amino substituents were fully characterized and constitute useful materials for coordination chemistry or building blocks for further transformations.