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Updated: Feb 7, 2026

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Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Sarah Fritzsche1, Raisatun Nisa Sugiyanto1,2, Kira Gür1

  • 1Institute of Pathology, University Hospital Heidelberg, Medical Faculty, Heidelberg University, Heidelberg, Germany.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 6, 2026
PubMed

Insights

Strawberry Notch 1 (SBNO1) drives liver cancer by regulating genes involved in cell growth and migration. Inhibiting SBNO1 reduced tumor development and progression in mouse models, highlighting its role in hepatocellular carcinoma and cholangiocarcinoma.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Aberrant Notch signaling is crucial in cancer development.
  • Strawberry notch (sno) knockout in Drosophila mimics Notch loss.
  • Strawberry Notch 1 (SBNO1) is implicated in various cancers.

Purpose of the Study:

  • To investigate the role of SBNO1 in liver cancer (HCC and CCA).
  • To understand SBNO1's mechanism in liver cancer progression.
  • To evaluate SBNO1 as a therapeutic target in liver cancer.

Main Methods:

  • Assessed SBNO1 protein levels in HCC and CCA tissues.
  • Utilized cell viability, colony formation, and migration assays.
  • Performed BioID to identify SBNO1 interacting proteins.
  • Inhibited SBNO1 in murine liver cancer models and analyzed tumor development.

Main Results:

  • SBNO1 protein is significantly increased in HCC and CCA, localized to the nucleus.
  • SBNO1 inhibition reduced HCC and CCA cell viability, colony formation, and migration.
  • SBNO1 binds to transcription factors TAF4 and TAF3, modulating gene expression.
  • SBNO1 deletion/inhibition significantly reduced liver tumor growth and development in vivo.
  • SBNO1 deletion impaired biliary differentiation and angiogenesis in CCA tumor margins.

Conclusions:

  • SBNO1 is a key transcriptional regulator upregulated in liver cancer.
  • SBNO1 is essential for liver cancer development and progression, particularly in Notch-driven CCA.
  • SBNO1 represents a potential therapeutic target for liver cancer treatment.
Keywords:
SBNO1cancercholangiocarcinomahepatocellular carcinomanotch signaling

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