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Updated: Feb 8, 2026

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A Two Birds with One Stone Strategy: Sialic Acid-Modified Pitavastatin Liposomes for Combating Atherosclerosis and

Shuang Lu1, Shuo Wang1, Xueying Tang1

  • 1College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.

Molecular Pharmaceutics
|February 6, 2026
PubMed

Insights

Targeted liposomes carrying pitavastatin (PIT-SAL) effectively treat atherosclerosis and tumors in mice. This novel drug delivery system shows promise for managing these interconnected diseases, even after treatment stops.

Area of Science:

  • Cardiovascular Research
  • Oncology
  • Drug Delivery Systems

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a growing global health concern.
  • Comorbidity of atherosclerosis (AS) and tumors necessitates innovative therapeutic strategies.
  • Liposomes offer a platform for targeted drug delivery.

Purpose of the Study:

  • To develop sialic acid-cholesterol (SA-CH) modified pitavastatin liposomes (PIT-SAL) for targeted delivery.
  • To evaluate the efficacy of PIT-SAL in treating atherosclerosis and tumors.
  • To investigate the therapeutic potential of PIT-SAL in managing interconnected diseases.

Main Methods:

  • Encapsulation of pitavastatin into liposomes.
  • Modification of liposomes with sialic acid-cholesterol (SA-CH) for targeting peripheral blood neutrophils (PBNs).
  • In vivo evaluation in atherosclerotic mouse models, assessing disease progression, therapeutic effects, tumoral cholesterol, and T-cell infiltration.

Main Results:

  • PIT-SAL demonstrated superior efficacy in attenuating atherosclerosis progression compared to oral pitavastatin.
  • Sustained therapeutic effects of PIT-SAL were observed even after treatment cessation.
  • PIT-SAL exhibited antitumor potential by reducing tumoral cholesterol and enhancing T-cell infiltration.

Conclusions:

  • PIT-SAL shows significant translational potential as a targeted therapy for both atherosclerosis and tumors.
  • This approach offers a promising breakthrough for managing interconnected AS and cancer.
  • Targeted liposomal delivery enhances therapeutic outcomes for complex diseases.
Keywords:
AtherosclerosisImmune plaqueLiposomeNeutrophilsPitavastatinTumor

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