Related Experiment Video

Updated: Feb 8, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

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Comprehensive analysis of PANoptosis-related molecular subtypes and prognostic model development of clear cell renal

Peng Zhou1, Zhen Xu1, Weidong Gan2

  • 1Department of Urology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China.

Discover Oncology
|February 6, 2026
PubMed
Abstract

Insights

Researchers identified PANoptosis-related genes (PRG) and developed a prognostic score for clear cell renal cell carcinoma (ccRCC). This score aids in assessing prognosis and predicting immunotherapy response in ccRCC patients.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Clear cell renal cell carcinoma (ccRCC) is highly heterogeneous with unpredictable treatment outcomes.
  • PANoptosis, a form of inflammatory programmed cell death, is implicated in tumor immunity but its role in ccRCC is not well understood.

Purpose of the Study:

  • To investigate the role of PANoptosis-related genes (PRG) in ccRCC.
  • To develop a prognostic score based on PRGs for ccRCC risk stratification.
  • To explore the therapeutic potential of PRGs in ccRCC.

Main Methods:

  • Utilized multi-omics data from TCGA for PRG characterization and subtype definition.
  • Developed a prognostic PRG score using Cox and LASSO regression.
  • Analyzed immune infiltration, drug sensitivity, and immunotherapy response.
  • Performed single-cell RNA sequencing and in vitro validation of RBCK1.

Main Results:

  • Identified 14 PRGs with significant alterations in ccRCC.
  • Defined three PRG molecular subtypes with distinct survival and immune profiles.
  • Developed a three-gene PRG score (RIPK1, PYCARD, RBCK1) that predicts prognosis, immune infiltration, and therapy sensitivity.
  • RBCK1 was found to be oncogenic, promoting ccRCC cell proliferation and migration.

Conclusions:

  • Established the PANoptosis landscape in ccRCC and created a prognostic PRG score.
  • RBCK1 is a key oncogenic driver and potential therapeutic target in ccRCC.
  • The findings provide a framework for precision medicine in ccRCC treatment.
Keywords:
Clear cell renal cell carcinomaImmune infiltrationMolecular subtypePANoptosisRisk stratification

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