Related Experiment Video
Updated: Feb 8, 2026
08:02
Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
Published on: July 3, 2018
11.1K
Vesicles for cell crosstalk in bone: composition, function and application
Chenhui Gu1,2, Yiyu Chen1,2, Pengyu Chen1,2
1Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Science China. Life Sciences
|February 6, 2026
Summary
Bone cells communicate via extracellular vesicles, including exosomes and microvesicles. This review covers their composition, function, and potential for diagnosing and treating bone diseases.
Area of Science:
- * Bone biology and cell communication.
- * Molecular and cellular biology.
- * Regenerative medicine and therapeutics.
Background:
- * Cellular crosstalk is crucial for bone homeostasis and function.
- * Bone is a key site for intercellular communication mediated by vesicles.
- * Extracellular vesicles (EVs) are critical mediators of this communication.
Purpose of the Study:
- * To review the composition and functions of bone-derived extracellular vesicles.
- * To explore the clinical applications of these vesicles in bone-related diseases.
- * To highlight recent advances and challenges in the field.
Main Methods:
- * Comprehensive literature review of extracellular vesicle research in bone biology.
- * Analysis of vesicle heterogeneity, biogenesis, and cargo.
- * Examination of diagnostic and therapeutic potential.
Main Results:
- * Bone-derived EVs (including exosomes, microvesicles, migrasomes) are heterogeneous and play roles in bone formation, resorption, and immunity.
- * EVs show promise as biomarkers for bone diseases.
- * EVs offer potential as therapeutic agents for bone regeneration and disease treatment.
Conclusions:
- * Extracellular vesicles are vital for bone cell communication and function.
- * Further research is needed to standardize EV isolation and overcome heterogeneity for clinical translation.
- * Understanding bone-derived EVs can offer insights into systemic organ interactions.
Related Concept Videos
01:19Composition of Polyprotic Acid Solutions as a Function of pH
869
Polyprotic acids of the type H2M constitute two ionizable protons. As a result, on titration with a base, they exhibit two equivalence points in the titration curve. During titration, the species H2M, HM−, and M2− will be present in the solution at different points. The fractions of H2M, HM−, and M2− present at the various instances of the titration are denoted by α0, α1, and α2, respectively.
A graph with the alpha values is plotted against the volume of...
A graph with the alpha values is plotted against the volume of...
869
03:35Classifying Matter by Composition
90.7K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.7K
01:27Applications of Integration to Probability Density Functions
70
Continuous probability distributions are used to model random variables that can take on any real value within a specified range. These variables do not take on isolated or countable values but rather exist on a continuum. For example, the height of an individual can be measured with increasing precision—such as 163.5 or 165.25 centimeters—demonstrating that height is a continuous random variable.The behavior of such variables is described using a probability density function (PDF),...
70
01:30Bone Cells and Tissue
8.4K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.4K
00:55Composite Bodies
1.4K
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
1.4K
01:22Composition of Blood
12.4K
The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...
Formed elements constitute the remaining 45% of the blood volume. These...
12.4K