High dietary ascorbic acid levels and oxalate crystallization in soft tissues of baboons

The baboon (Papio ursinus) was used as a model to investigate the possibility of oxalate crystallization in the soft tissues due to long-term feeding of ascorbic acid in high doses. Microscopical inspection in polarized light did not reveal oxalate crystals in any of the soft tissues obtained from 16 baboons fed very high doses of ascorbic acid for a period of 20 months.