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Updated: Feb 8, 2026
07:59
Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
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Hyperbaric oxygen therapy for skin flap transplantation: a meta-analysis
Zhenhua He1, Xiaofen Sun2, Jinfang Chen3
1Shaoxing Institute of Technology, Shaoxin, China.
Journal of Wound Care
|February 6, 2026
Summary
Hyperbaric oxygen therapy (HBOT) significantly improves skin flap survival and accelerates recovery after transplantation. This therapy enhances skin oxygen saturation and temperature while reducing swelling and improving skin color return.
Area of Science:
- Plastic Surgery
- Regenerative Medicine
- Hyperbaric Medicine
Background:
- Skin flap transplantation is crucial for reconstruction but faces challenges with necrosis.
- Hyperbaric oxygen therapy (HBOT) is explored for its potential to improve outcomes in these procedures.
Purpose of the Study:
- To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in enhancing wound healing and survival rates of skin flaps post-transplantation through a meta-analysis.
Main Methods:
- A comprehensive search of multiple databases (PubMed, Web of Science, etc.) was conducted up to June 2023.
- Included 13 randomized controlled trials (RCTs) involving 1226 patients undergoing skin flap transplantation.
- Data analysis was performed using RevMan 5.3 statistical software.
Main Results:
- HBOT significantly increased skin flap survival rates (OR: 8.57; 95% CI: 5.54, 13.26).
- Improved skin blood oxygen saturation (MD: 19.94) and postoperative skin temperature (MD: 0.71).
- Reduced time for swelling subsidence (MD: -3.76) and skin ruddy return (MD: -4.56).
Conclusions:
- Hyperbaric oxygen therapy (HBOT) is effective in improving skin flap survival rates.
- HBOT accelerates skin recovery, evidenced by improved oxygen saturation, temperature, and reduced recovery times.
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