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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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C-reactive protein-triglyceride-glucose index versus triglyceride-glucose index in predicting cardiovascular

Hongjin Wang1, Ming Yang2, Wenjing Cai3

  • 1Department of Cardio-Thoracic Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

Plos One
|February 6, 2026
PubMed

Insights

The novel C-reactive protein-triglyceride-glucose index (CTI) shows superior accuracy in predicting Cardiovascular Metabolic Multimorbidity (CMM) risk compared to the Triglyceride-Glucose (TyG) index. This finding supports CTI

Area of Science:

  • Cardiovascular disease research
  • Metabolic syndrome research
  • Biomarker discovery

Background:

  • Cardiovascular Metabolic Multimorbidity (CMM) is a major global health concern.
  • Existing risk prediction models for CMM require further refinement.
  • The C-reactive protein-triglyceride-glucose index (CTI) integrates inflammation and insulin resistance, offering a novel approach.

Purpose of the Study:

  • To evaluate the predictive utility of the C-reactive protein-triglyceride-glucose index (CTI) for Cardiovascular Metabolic Multimorbidity (CMM) risk.
  • To compare the predictive performance of CTI against the established Triglyceride-Glucose (TyG) index.
  • To investigate the dose-response relationship and subgroup variations in CMM risk prediction by CTI and TyG.

Main Methods:

  • Analysis of 8,487 adults aged ≥45 from the Chinese Health and Retirement Longitudinal Study (CHARLS) database (2011-2020).
  • Utilized Cox regression, restricted cubic spline (RCS), and Receiver Operating Characteristic (ROC) curve analyses to assess associations.
  • Conducted subgroup analyses to examine population-specific variations in predictive accuracy.

Main Results:

  • Both TyG and CTI independently predicted CMM risk, with a significant dose-response association observed for both indices.
  • The C-reactive protein-triglyceride-glucose index (CTI) demonstrated superior predictive accuracy compared to the Triglyceride-Glucose (TyG) index, as indicated by ROC analysis (higher AUC).
  • Subgroup analyses revealed that the association of TyG with CMM risk varied by sex, smoking, and hypertension, while CTI's association differed by age, sex, and hypertension.

Conclusions:

  • Elevated C-reactive protein-triglyceride-glucose index (CTI) is independently associated with an increased risk of Cardiovascular Metabolic Multimorbidity (CMM).
  • CTI exhibits superior predictive performance for CMM compared to the Triglyceride-Glucose (TyG) index.
  • The linear association and enhanced predictive accuracy of CTI suggest its potential clinical utility for early CMM risk stratification.
Abstract

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