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Updated: Feb 8, 2026

A Mouse Model for Laser-induced Choroidal Neovascularization
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A Mouse Model for Laser-induced Choroidal Neovascularization

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Ethyl ferulate suppresses choroidal neovascularization by accelerating Keap1 degradation through the inhibition of

Rong Xue1, Yi-Chen Dong2, Xia Wang2

  • 1Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Henan Province Engineering Research Center of Fundus Disease and Ocular Trauma Prevention and Treatment, Zhengzhou, Henan 450052, PR China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|February 6, 2026
PubMed
Abstract

Insights

Ethyl ferulate effectively treats choroidal neovascularization (CNV) by inhibiting PSMD14 and activating the Nrf2 antioxidant pathway. This natural compound shows promise for future CNV therapies.

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Pharmacology

Background:

  • Choroidal neovascularization (CNV) is a major cause of vision loss with limited treatments.
  • Ethyl ferulate, a natural compound, possesses antioxidant and anti-angiogenic properties.
  • Its therapeutic potential and mechanisms for CNV remain largely uninvestigated.

Purpose of the Study:

  • To assess the therapeutic efficacy of ethyl ferulate in a mouse model of CNV.
  • To elucidate the molecular mechanisms underlying ethyl ferulate's effects on CNV.

Main Methods:

  • CNV was induced in mice, followed by intravitreal ethyl ferulate injections.
  • Ocular assessments included fundus fluorescein angiography and OCT.
  • In vitro studies utilized RPE and endothelial cells to investigate anti-angiogenic and molecular pathways.

Main Results:

  • Ethyl ferulate significantly reduced CNV in vivo and inhibited endothelial cell proliferation, migration, and tube formation in vitro.
  • Ethyl ferulate decreased PSMD14 expression, leading to Keap1 degradation and Nrf2 pathway activation.
  • Downregulation of MAZ by ethyl ferulate reduced PSMD14 transcription.

Conclusions:

  • Ethyl ferulate suppresses CNV by inhibiting PSMD14 and activating the Keap1/Nrf2 pathway.
  • These findings highlight ethyl ferulate as a potential therapeutic candidate for CNV.
Keywords:
Choroidal neovascularizationEthyl ferulateKeap1PSMD14Ubiquitination

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