Related Experiment Video

Updated: Feb 8, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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A potent novel small molecule GLP-1R agonist identified by rational design and CADD

Jiayu Chen1, Yuanshan Yao2, Hao Li3

  • 1State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, and School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Bioorganic & Medicinal Chemistry
|February 6, 2026
PubMed
Abstract

Keywords:
CADDCompetitive binding affinityIPGTTRationale designSARSmall molecule GLP-1R agonist

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