Related Experiment Video
Updated: Feb 8, 2026
08:25
Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method
Published on: December 25, 2016
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Influence of exercise training on nitric oxide pathways and their physiological effects
Jonas Benjamim1, Stephen J Bailey2, Leonardo da Silva Gonçalves3
1Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, Victoria, Australia.
Redox Biology
|February 6, 2026
Summary
Exercise may boost nitric oxide (NO) production through both the NOS pathway and the nitrate-nitrite-NO pathway. It also influences oral microbiota, potentially enhancing NO metabolism and oral health.
Area of Science:
- Physiology
- Microbiology
- Exercise Science
Background:
- Nitric oxide (NO) is vital for cardiovascular, metabolic, and muscular functions.
- Endogenous NO is produced via the nitric oxide synthases (NOS) pathway and the nitrate-nitrite-NO pathway.
- The nitrate-nitrite-NO pathway involves oral microbiota reducing nitrate (NO3-) to nitrite (NO2-).
Purpose of the Study:
- To review how physical exercise modulates both NO production pathways.
- To explore the influence of exercise on oral microbiota and NO metabolism.
- To discuss the physiological implications of exercise-induced NO modulation.
Main Methods:
- Literature review of current evidence.
- Synthesis of findings on exercise and NO pathways.
- Discussion of exercise's impact on oral microbiota and NO metabolism.
Main Results:
- Exercise training enhances NOS-derived NO production.
- Exercise may increase NO bioavailability via the nitrate-nitrite-NO pathway.
- Exercise can alter oral microbiota composition and function, affecting NO metabolism.
Conclusions:
- Physical exercise influences multiple NO production pathways.
- Exercise and oral microbiota may have synergistic effects on NO metabolism.
- Further research is needed to understand these combined effects on physiological function and oral health.
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