Related Experiment Video
Updated: Feb 8, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Reactive oxygen species driven immune inflammation in systemic sclerosis: mechanisms and emerging therapeutics
Shih-Ching Lee1, Kuang-Hui Yu2, Hsuan-Cheng Huang3
1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 106, Taiwan; Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; Division of Rheumatology, Allergy and Immunology, New Taipei Municipal Tucheng Hospital, New Taipei City 236, Taiwan.
Abstract:
Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular abnormalities, immune dysregulation, and progressive fibrosis of the skin and internal organs. Oxidative stress is thought to be a potential initiating factor in SSc vasculopathy, with sustained reactive oxygen species (ROS) production implicated in disease progression and tissue fibrosis. Immunosuppressants have been used to treat SSc, and there are still unmet clinical needs. This review highlights newly validated and investigational therapies targeting ROS-driven immune and cytokine pathways, which have key roles in the initiation and progression of SSc-related vasculopathy and fibrosis.
Related Concept Videos
Mechanical Systems
Inflammation
Electro-mechanical Systems
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
What is a Species?
Formation of Species
Emerging Adulthood

