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Updated: Feb 8, 2026

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
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Association between beta-blocker use and outcomes in patients with sepsis-induced myocardial injury: An analysis

Han Wu1, Linqian Jiang2, Liman Qiu3

  • 1Department of Anesthesiology, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, PR China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|February 6, 2026
PubMed
Abstract

Insights

Beta-blocker therapy in sepsis-induced myocardial injury (SIMI) significantly reduces in-hospital and long-term mortality. This large-scale study provides crucial evidence supporting beta-blocker use in SIMI patients, especially the severely ill.

Area of Science:

  • Critical Care Medicine
  • Cardiology
  • Pharmacology

Background:

  • Sepsis-induced myocardial injury (SIMI) is a critical condition associated with high mortality rates.
  • The role of beta-blocker therapy in managing SIMI is not well-established due to a lack of large-scale evidence.

Purpose of the Study:

  • To investigate the impact of beta-blocker administration on mortality outcomes in patients with sepsis-induced myocardial injury.
  • To leverage large real-world datasets (MIMIC-IV and eICU) for robust clinical insights.

Main Methods:

  • A retrospective cohort study utilizing the MIMIC-IV and eICU databases.
  • Inclusion criteria: Adult patients meeting Sepsis-3.0 criteria with elevated cardiac troponin.
  • Propensity score matching (1:1) and sensitivity analyses were employed to ensure result validity.

Main Results:

  • Beta-blocker use was linked to a significant decrease in in-hospital mortality across both datasets post-propensity score matching.
  • Long-term survival benefits were observed, with reduced 28-day, 90-day, and 1-year mortality rates.
  • Severely ill patients (SOFA score ≥8) experienced the most substantial mortality reduction with beta-blocker use.

Conclusions:

  • Beta-blocker therapy is associated with improved survival rates in patients suffering from sepsis-induced myocardial injury.
  • The findings suggest a potential benefit of beta-blockers in SIMI, warranting further investigation through prospective clinical trials.
Keywords:
Intensive care unitMortalitySepsisSepsis-induced myocardial injuryβ-blockers

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