Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

66.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.3K
Master Transcription Regulators02:23

Master Transcription Regulators

7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Abnormal Proliferation02:23

Abnormal Proliferation

5.2K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Perpendicular-Axis Theorem01:16

Perpendicular-Axis Theorem

4.6K
The perpendicular-axis theorem states that the moment of inertia of a planar object about an axis perpendicular to its plane is equal to the sum of the moments of inertia about two mutually perpendicular concurrent axes lying in the plane of the body.
Consider a circular disc of mass M and radius R lying along an x-y plane. The origin lies at the center of the disc, and the z-axis is perpendicular to the disc's plane. All three axes coincide at the disc's center. The moment of inertia of this...
4.6K
Parallel-axis Theorem01:06

Parallel-axis Theorem

8.3K
The parallel-axis theorem provides a convenient and quick method of finding the moment of inertia of an object about an axis parallel to the axis passing through its center of mass. Consider a thin rod as an example. There is a striking similarity between the process of finding the moment of inertia of a thin rod about an axis through its middle, where the center of mass lies, and about an axis through its end using the conventional method. In the conventional method, the concept of linear mass...
8.3K
Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective killing of ALT-cancer cells by Withaferin-A involves destabilization of Rad51 and disruption of DNA repair.

Cell death & disease·2026
Same author

Bridging the anatomical gap: evolutionary conservation of genetic mechanisms in corpus callosum disorders across human, mouse, and zebrafish.

Frontiers in molecular neuroscience·2026
Same author

Molecular Insights into the Neurogenic Potential of Alpha-lipoic Acid.

Current topics in medicinal chemistry·2026
Same author

pH-responsive dual-drug-loaded bovine serum albumin nanoparticles for targeted cancer therapy.

International journal of biological macromolecules·2026
Same author

DPYD genotyping in patients receiving capecitabine: an exploratory analysis from the D-TORCH study.

Frontiers in pharmacology·2026
Same author

Nano Enabled Dual-Responsive Drug Carrier Originated from Acetalated Dextran/Carboxylated Nanocellulose-Based Core-Shell Microspheres.

ACS biomaterials science & engineering·2026

Related Experiment Video

Updated: Feb 8, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.5K

The HCF-1:OGT axis regulates neuronal proliferation and differentiation.

Ayushma1, Priyanka Prakash Srivastava1, Shruti Kaushal2

  • 1Kusuma School of Biological Sciences, Indian Institute of Technology Delhi (IITD), Hauz Khas, New Delhi 110016, India.

Neurobiology of Disease
|February 6, 2026
PubMed
Summary

Host Cell Factor-1 (HCF-1) is crucial for brain development and neuronal differentiation. Its disruption, linked to intellectual disability, impairs forebrain organization and neuronal survival, offering insights into neurodevelopmental disorders.

Keywords:
DifferentiationHCF-1Host cell factor 1NeuronsNkx2.1O-linked N-acetylglucosamine transferaseOGT

More Related Videos

Isolation, Proliferation and Differentiation of Rhesus Macaque Adipose-Derived Stem Cells
07:33

Isolation, Proliferation and Differentiation of Rhesus Macaque Adipose-Derived Stem Cells

Published on: May 26, 2021

2.5K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.6K

Related Experiment Videos

Last Updated: Feb 8, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.5K
Isolation, Proliferation and Differentiation of Rhesus Macaque Adipose-Derived Stem Cells
07:33

Isolation, Proliferation and Differentiation of Rhesus Macaque Adipose-Derived Stem Cells

Published on: May 26, 2021

2.5K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.6K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Neuronal differentiation requires complex coordination of cell processes.
  • Host Cell Factor-1 (HCF-1), an X-linked transcriptional co-regulator, is vital for development but its role in neurogenesis is unclear.
  • HCF-1 is linked to human intellectual disability.

Purpose of the Study:

  • To investigate the function of the HCF-1-OGT axis in neuronal differentiation and forebrain development.
  • To define the lineage-specific roles of HCF-1 in mammalian neurogenesis.

Main Methods:

  • Conditional deletion of HCF-1 in specific neuronal lineages (Nkx2.1-derived).
  • Transcriptomic profiling to analyze gene expression changes.
  • In vitro studies on neuronal proliferation, differentiation, and neurite outgrowth.
  • Glycoproteomic analysis to study OGT-dependent protein networks.

Main Results:

  • Loss of HCF-1 in neuronal lineages caused cortical disorganization, reduced GABAergic interneuron survival, and forebrain commissure defects.
  • HCF-1 depletion dysregulated gene networks involved in neuronal differentiation, chromatin regulation, and axon guidance.
  • In vitro, HCF-1 or OGT inhibition impaired neuronal proliferation, differentiation, and neurite outgrowth.

Conclusions:

  • HCF-1 is a key regulator of neuronal differentiation and forebrain organization.
  • Disruption of the HCF-1-OGT axis contributes to neurodevelopmental disorders.
  • Findings provide mechanistic insights into HCF-1's role in neurodevelopment.