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Pathophysiology and Management of Sepsis-associated Acute Kidney Injury
Shina Menon1, Sarah Sanghavi2, Javier A Neyra3
1Division of Nephrology, Department of Pediatrics, Lucile Packard Children's Hospital, Stanford University School of Medicine, Palo Alto, CA, USA.
Clinics in Chest Medicine
|February 6, 2026
Summary
Sepsis-associated acute kidney injury (SA-AKI) is a critical condition impacting the kidneys during sepsis. Research focuses on understanding its complex causes and improving patient outcomes with new treatments.
Area of Science:
- Nephrology
- Critical Care Medicine
- Immunology
Background:
- Sepsis-associated acute kidney injury (SA-AKI) is a severe complication in critically ill patients.
- It arises from a dysregulated immune response to infection, causing organ dysfunction.
- SA-AKI is associated with increased need for renal replacement therapy and poor long-term prognosis.
Purpose of the Study:
- To summarize the complex pathophysiology of SA-AKI.
- To highlight current management strategies and the lack of specific pharmacotherapies.
- To discuss emerging research in risk stratification, subphenotyping, and precision medicine for SA-AKI.
Main Methods:
- Literature review of SA-AKI pathophysiology.
- Analysis of current clinical management approaches.
- Overview of ongoing research directions in SA-AKI.
Main Results:
- SA-AKI involves multifactorial processes including inflammation and endothelial damage.
- Current management relies on prevention and supportive care.
- Novel interventions and precision medicine are under investigation.
Conclusions:
- SA-AKI presents a significant clinical challenge with complex underlying mechanisms.
- Improved diagnostic and therapeutic strategies are needed.
- Future research aims to personalize treatment and enhance patient survival and recovery.
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