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Updated: Feb 8, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
Published on: April 11, 2012
Pediatric Sepsis: Evolving Subphenotypes, Overlap Syndromes, and the Path to Precision Therapies
Steven D Ham1, Julie C Fitzgerald1, Robert B Lindell2
1Division of Critical Care Medicine, Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Pediatric Sepsis Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
None:
Pediatric sepsis is a complex syndrome shaped by developmental considerations, age-specific physiology, immunologic heterogeneity, and hyperinflammatory overlap syndromes. Recent evidence underscores a dynamic interplay between hyperinflammation and immunoparalysis in pediatric patients with sepsis, emphasizing the need for rapid, personalized diagnostic tools. While revised pediatric scoring systems and targeted immunotherapies have been developed, significant knowledge gaps remain regarding optimal timing and patient selection for immunomodulatory interventions. This article consolidates current understanding of pediatric sepsis pathobiology, explores emerging pediatric subphenotypes, and examines early stage clinical trials investigating precision medicine approaches in pediatric sepsis.
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