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Acute Inflammation II: Local and Systemic Effects

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Updated: May 2, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Microcirculatory Dysfunction in Sepsis.

Max S Kravitz¹, Nathan I Shapiro¹, Eric P Schmidt²

¹Department of Emergency Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Clinics in Chest Medicine

|February 6, 2026

Summary

This summary is machine-generated.

Microcirculatory dysfunction in sepsis is linked to poor outcomes. Precision medicine using microcirculatory measurements may guide individualized treatments for better sepsis management.

Keywords:

Endothelium Glycocalyx Intravital microscopy Microcirculation Microvascular dysfunction Precision medicine Resuscitation strategies Sepsis

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A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Area of Science:

Critical care medicine
Physiology
Sepsis research

Background:

Microcirculatory dysfunction is a key factor in sepsis pathophysiology.
It is strongly associated with adverse clinical outcomes in sepsis patients.
Current therapies targeting microcirculation have shown limited success in improving outcomes.

Purpose of the Study:

To review current evidence on microvascular dysfunction in sepsis.
To discuss physiology, assessment, and therapeutic strategies.
To highlight the need for precision medicine in sepsis resuscitation.

Main Methods:

Literature review of current evidence.
Analysis of physiological mechanisms.
Evaluation of diagnostic tools and biomarkers.
Assessment of therapeutic interventions.

Main Results:

Microcirculatory dysfunction significantly impacts sepsis outcomes.
Bedside tools and biomarkers show promise for detection.
Most current therapies have not improved clinical outcomes.
Precision medicine approaches are needed for individualized care.

Conclusions:

Microvascular dysfunction is central to sepsis.
Precision medicine, guided by microcirculatory measurements, is crucial for individualized resuscitation.
Further research into patient subgroups benefiting from targeted interventions is warranted.