Microcirculatory Dysfunction in Sepsis
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Updated: May 2, 2026
Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Max S Kravitz1, Nathan I Shapiro1, Eric P Schmidt2
1Department of Emergency Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Abstract:
Microcirculatory dysfunction plays a central role in sepsis pathophysiology and is associated with poor clinical outcomes. While advances in bedside tools and biomarkers offer potential for identifying microcirculatory dysfunction, most therapies targeting the microcirculation have not translated into improved clinical outcomes. Future advances likely lie in precision medicine approaches that employ microcirculatory measurements to guide individualized resuscitation strategies. This article highlights current evidence on the physiology, assessment, and therapeutic approaches to microvascular dysfunction in sepsis, underscoring the need for precision medicine strategies and further research into patient subgroups that may benefit from microcirculation directed interventions.
Insights
Microcirculatory dysfunction in sepsis is linked to poor outcomes. Precision medicine using microcirculatory measurements may guide individualized treatments for better sepsis management.
Area of Science:
- Critical care medicine
- Physiology
- Sepsis research
Background:
- Microcirculatory dysfunction is a key factor in sepsis pathophysiology.
- It is strongly associated with adverse clinical outcomes in sepsis patients.
- Current therapies targeting microcirculation have shown limited success in improving outcomes.
Purpose of the Study:
- To review current evidence on microvascular dysfunction in sepsis.
- To discuss physiology, assessment, and therapeutic strategies.
- To highlight the need for precision medicine in sepsis resuscitation.
Main Methods:
- Literature review of current evidence.
- Analysis of physiological mechanisms.
- Evaluation of diagnostic tools and biomarkers.
- Assessment of therapeutic interventions.
Main Results:
- Microcirculatory dysfunction significantly impacts sepsis outcomes.
- Bedside tools and biomarkers show promise for detection.
- Most current therapies have not improved clinical outcomes.
- Precision medicine approaches are needed for individualized care.
Conclusions:
- Microvascular dysfunction is central to sepsis.
- Precision medicine, guided by microcirculatory measurements, is crucial for individualized resuscitation.
- Further research into patient subgroups benefiting from targeted interventions is warranted.
