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Updated: Jul 13, 2026

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
Published on: June 23, 2009
Cutaneous Histiocytoses
Karen L Rech1, Angela M Collie1
1Division of Hematopathology, Department of Laboratory Medicine and Pathology, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA.
Abstract:
The main categories of cutaneous histiocytoses include Langerhans cell histiocytosis, indeterminate cell histiocytosis, juvenile or adult xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, ALK-positive histiocytosis and malignant histiocytic neoplasms. A minimum immunohistochemical panel including CD68 or CD163, S100, CD1a, langerin, and BRAF V600E, combined with morphologic features can establish a histologic diagnosis. Because these disorders may be limited to the skin or be a manifestation of a systemic histiocytic neoplasm, correlation with clinical features is essential. Molecular genetic analysis to identify mutations in the mitogen-activated protein kinase pathway should be considered to provide options for targeted therapy.
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