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Updated: Feb 8, 2026

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
Published on: June 23, 2009
ALK Rearrangements in Cutaneous Tumors: Molecular Insights and Emerging Entities.
David J Papke1, Mia S DeSimone1
1Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA.
Anaplastic lymphoma kinase (ALK) rearrangements define various skin tumors. Identifying these ALK alterations is crucial for diagnosing and managing these diverse cutaneous neoplasms.
Area of Science:
- Oncology
- Dermatopathology
- Molecular Pathology
Background:
- Anaplastic lymphoma kinase (ALK) rearrangements are increasingly recognized as key molecular drivers in various neoplasms.
- Cutaneous neoplasms, including mesenchymal and melanocytic types, exhibit diverse features.
- ALK alterations play a significant role in the pathogenesis of these tumors.
Purpose of the Study:
- To describe distinct types of ALK-rearranged cutaneous neoplasms.
- To highlight the diagnostic importance of ALK alterations in skin tumors.
- To emphasize an integrated diagnostic approach for accurate classification and management.
Main Methods:
- Review of distinct ALK-rearranged cutaneous neoplasms.
- Immunohistochemistry for ALK overexpression detection.
- Confirmatory molecular testing when indicated.
Main Results:
- Several distinct ALK-rearranged cutaneous neoplasms identified, including epithelioid fibrous histiocytoma, superficial ALK-rearranged myxoid spindle cell neoplasm, nonneural granular cell tumor, and Spitz melanocytic neoplasms.
- ALK overexpression is a critical diagnostic marker.
- An expanding spectrum of ALK-rearranged tumors is being recognized.
Conclusions:
- ALK rearrangements are a unifying molecular feature in a diverse range of cutaneous neoplasms.
- Accurate diagnosis relies on recognizing these entities and utilizing ALK testing.
- An integrated diagnostic strategy is essential for optimal patient care.
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